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Clinical Chemistry

Concepts and Applications, Revised Edition

Shauna C. Anderson and Susan Cockayne

Clinical Chemistry melds the basics of laboratory medicine in chemistry, physiology, and pathology with an emphasis on the concepts of clinical chemistry, the mechanisms of diseases, and the correlation of laboratory data. The scope of the text is broad, extending traditional boundaries to include immunology and endocrinology. It includes analytes, pathophysiology, methodology, clinical correlations/lab diagnosis, and concept applications, making the content widely applicable for discussions of special populations and assessments.

Chapters illustrating laboratory safety, calculations, and resources; quality assurance; automation; and spectrophotometry will help students transition to the clinical laboratory work environment. The reader-friendly design provides an inclusive discussion of the principles of procedures, as well as parallels the curriculum published by the American Society of Clinical Laboratory Scientists.

$73.95 list, 725 pages

10-digit ISBN: 1-57766-514-7

13-digit ISBN: 978-1-57766-514-4

© 2003

Instructor's Guide available

Table of Contents

1. Laboratory Resources (Mary Coleman)

Pipets / Dispensers / Glassware and Plasticware / Cleaning Labware / Chemical Reagents and Handling / Reference Materials and Controls / Water Purification / Basic Chemistry Eequipment

2. Laboratory Reagents and Calculations (Susan Cockayne)

Reagents / Standards / Laboratory Calculations

3. Laboratory Safety (Jean D. Holter)

Regulations / Safety Practices / Fire Safety / Chemical Safety / Compressed Gases / Electrical Safety / Biological Safety / Radiation Safety / Laboratory Safety Program

4. Quality Assurance (Mark D. Kellogg)

The Quality Management Framework / Quality Control Monitoring

5. Method Evaluation and Preanalytical Variables (Mary Coleman)

Method Evaluation / Reference Intervals / Preanalytical Variables / Components of an Effective CQI/QA Program

6. Spectrophotometry (Jane E. Aldrich)

Spectrophotometric Principles / Spectrophotometric Instruments

7. Principles of Molecular and Immunoassays (Audrey E. Hentzen)

Introduction / Specimen Collection and Handling / Immunoassays / Enzyme Labels / Fluorescent Labels / Molecular Assays

8. Laboratory Automation (Jean D. Holter)

Robotics / Stages of Automated Analysis / Examples of Specific Systems / Instrument Selection

9. Computers in the Clinical Laboratory (Mark D. Kellogg)

Computer Hardware and Software / Networking and Communication / Laboratory Information Systems / Medical Informatics

10. Carbohydrates (Margot Hall)

Definitions and Basic Principles / Classification / Metabolism / Hormonal Regulation / Clinical Applications / Cerebrospinal Fluid Glucose / Analytical Procedures

11. Lipids (Robert C. Mroz, Jr.)

Classification of Lipids / Metabolism of Lipids / Lipoproteins / Analytical Procedures for Lipids / Pathophysiology

12. Proteins (Joan Radtke)

Classification / Metabolism: Synthesis and Degradation / General Analytical Processes / Clinical Applications / Protein in Other Body Fluids

13. Inherited Metabolic Disorders (Jane Adrian)

Overview of Genetic Disorders / Clinical Applications in Detecting Metabolic Related Disorders / Analytical Procedures: Past, Present, and Anticipated

14. Immunologic Disorders (Audrey E. Hentzen)

Autoimmunity / Clinical Applications

15. Clinical Enzymology (Joan E. Aldrich)

Measuring Enzymes / Clinically Significant Enzymes / Clinical Applications

16. Liver Function (Lynn R. Ingram)

Liver Anatomy / Liver Function / Analytical Procedures / Clinical Applications

17. Tumor Markers (Margot Hall)

Characteristics of an Ideal Tumor Marker / Uses of Tumor Markers / Biologic Sources / Classification / Clinical Applications / New Directions

18. Porphyrins (Susan Cockayne)

Biosynthesis of Porphyrins and Heme / Clinical Applications / Laboratory Diagnosis of Porphyrin Disorders / Analytical Procedures

19. Renal Anatomy and Physiology (Nancy A. Brunzel)

Renal Anatomy / Renal Physiology

20. Renal Function: Nonprotein Nitrogen Compounds, Function Tests, and Renal Disease

Nonprotein Nitrogen Compounds / Assessment of Renal Function / Clinical Applications

21. Electrolytes (Richard C. Mroz, Jr.)

Total Body Water / Osmolality / Electrolytes / Analytical Procedures

22. Acid-Base and Blood Gas Physiology (Lisa J. Johnson)

Clinically Important Gases / Maintenance of Acid-Base Balance / Disturbances of Acid-Base Balance / Laboratory Evaluation / The Extended Laboratory

23. Therapeutic Drug Monitoring (Susan Cockayne)

Drug Action / Drug Disposition / Pharmacokinetics / Variable Affecting Drug Disposition / Sample Collection and Data Reporting / Therapeutic Drug Monitoring

24. Toxicology (Joan Radtke)

Classes of Toxic Substances / Drugs of Abuse and Overdose / Analytical Procedures

25. Introduction to Hormones and Endocrinology (Jocelyn J. Hulsebus)

Classification of Hormones / Regulation of Hormone Secretion / Mechanisms of Action / Disorders of the Endocrine System

26. Hypothalamus and Pituitary Endocrinology (Jocelyn J. Hulsebus)

Hypothalamus / Pineal Gland / Pituitary (Hypophysis) Gland

27. Thyroid Endocrinology (Marcia H. Hicks)

Thyroid Anatomy / Thyroid Physiology / Thyroid Function Testing / Clinical Applications

28. The Parathyroid Glands and Calcium-Phosphate Metabolism (Susan Cockayne and Shauna C. Anderson)

Anatomy / Parathyroid Hormone / Regulation of Calcium and Phosphorus / Specific Analytes / Clinical Applications

29. Adrenocortical Endocrinology (Jocelyn J. Hulsebus)

Anatomy / Adrenal Hormones / Adrenal Function Tests / Clinical Applications

30. Adrenal Medullary Endocrinology (Jocelyn J. Hulsebus)

Anatomy / Adrenal Medullary Hormones / Clinical Applications

31. Reproductive Endocrinology (George B. Kudolo)

Male Reproductive System / Female Reproductive System / Structure and Function of Gonadal Steroids / Mechanism of Hormone Action / Analytes / Clinical Applications / Defects of Androgen Metabolism / Gonadal Function Tests

32. Gastrointestinal and Pancreatic Function (Claudia E. Miller)

Gastrointestinal Organs / Accessory Organs / Digestion / Regulation of Digestion by Gastrointestinal Hormones / Clinical Applications / Laboratory Diagnosis of Dysfunction

33. Nutritional Status Assessment (Sharon M. Miller and Elia Mears)

Nutritional Status / Proteins / Vitamins and Mineral Status / Trace and Ultratrace Elements

34. Point-of-Care Testing (Jean D. Holter)

The POCT Laboratory / Evaluation / POCT Testing and Instrumentation / Billing

35. Laboratory Assessment of Psychiatric Disorders (Jane Adrian)

Supporting the Psychiatric Diagnosis and Plan of Treatment / Medical Conditions Underlying Diagnosis and Treatment / Screening for the Biochemical Basis of Psychiatric Disorders / Monitoring Therapeutic Treatment

36. Biochemical Assessment During Pregnancy (George B. Kudolo)

Biochemical Changes / Analytes / Clinical Applications

37. Neonatal and Pediatric Laboratory Assessment (Eileen Carreiro-Lewandowski)

Developmental Differences / Perinatal Physiology / Laboratory Assessment in the Pediatric Population

38. Geriatric Laboratory Assessment (Sharon M. Miller)

The "New" Elderly / Theories of Aging / Biochemical Changes / Nutrition in Aging / Vitamin Status / Reference Ranges / Clinical Applications